A Handbook for DNA-Encoded Chemistry: Theory and by Robert A. Goodnow Jr.

By Robert A. Goodnow Jr.

This e-book comprehensively describes the advance and perform of DNA-encoded library synthesis expertise. jointly, the chapters element an method of drug discovery that provides an enticing addition to the portfolio of latest hit iteration applied sciences akin to high-throughput screening, structure-based drug discovery and fragment-based screening. The book:

  • Provides a invaluable consultant for knowing and making use of DNA-encoded combinatorial chemistry
  • Helps chemists generate and display novel chemical libraries of enormous measurement and caliber
  • Bridges interdisciplinary parts of DNA-encoded combinatorial chemistry – artificial and analytical chemistry, molecular biology, informatics, and biochemistry
  • Shows medicinal and pharmaceutical chemists easy methods to successfully increase on hand “chemical house” for drug discovery
  • Provides specialist and up to date precis of said literature for DNA-encoded and DNA-directed chemistry expertise and methods

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Extra resources for A Handbook for DNA-Encoded Chemistry: Theory and Applications for Exploring Chemical Space and Drug Discovery

Sample text

DNA bases. 3. Structure of AGTT. , while numbers without prime notation are used for atoms in bases. Phosphodiester bonds link 3′- and 5′-hydroxyl groups of neighboring 2-deoxy-d-ribose molecules, forming a DNA backbone. Due to this architecture, a DNA molecule has so-called 5′- and 3′-ends and possesses a defined polarity or direction. The sequence of bases in DNA is conventionally written from left to right starting at the base at the 5′-end and continuing to 3′-end. For simplicity, the prefixes 5′- and 3′- are sometimes dropped.

Parallel synthesis is the performance of a common synthetic step or steps while simultaneously varying a single diversity reagent. Often, a common core synthon is used in this approach. Parallel chemistry is one of the simplest methods for obtaining small numbers of compounds. It requires little more preparation than would be necessary for the standard analog synthesis that most organic chemists perform. •• Solid-phase synthesis refers to synthetic procedures that are conducted by attaching at least one reaction component to a substance that is insoluble in the reaction solvent.

Furka Theoretical basis to create large numbers of compounds 8. 1992 Encoding with DNA S. Brenner and Concept experiment for R. A. Lerner using DNA to encode small-molecule synthesis 9. 1993 Encoding split-and- M. A. Gallop Synthesis and encoding of pool libraries with approximately one DNA million peptides with DNA-based encoding 10. 1993 Haloaromatic binary W. C. Still Split-and-pool, coding solid-phase synthesis with haloaromatic binary encoding 11. 1995 Radio frequency K. C. Nicolaou Commercially available and E.

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